Drugscore^PPI is a knowledge-based scoring function for computational alanine-scanning in protein-protein interfaces. The PDB-derived statistical potentials have been fine-tuned by an atomtype-based QSAR approach with respect to experimental binding free energy differences between wildtype proteins and ALA mutants for protein-protein complex formation. DrugScore^PPI is therefore dedicated to successfully identify hot spots in protein-protein interfaces.

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Krüger, D.M., Gohlke, H. DrugScore^PPI webserver: Fast and accurate in silico alanine scanning for scoring protein-protein interactions. Nucleic Acids Res. 2010, 38, W480-W486, doi: 10.1093/nar/gkq471. [PubMed]

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