In silico alanine scanning

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 © CPC lab, 2009

Version 2.2


Alternative sidechain conformations in the interface are not allowed.


- Hydrogens are not required and are not considered.

- Peptide ligands can be scanned if they only contain standard amino acids. For this purpose, ligand entries in the PDB file have to be modified: Please change HETATM to ATOM entries and define a chain identifier of your choice.

- Make sure that you select the right chain(s). Select only the chains that should be mutated.

Important: If you want to perform alanine scanning for both of two oppositely arranged polypeptide chains, you have to scan each of the chains SEPARATELY.

- Make sure that you select all chains from the protein of your interest. Otherwise, calculation of INTRAmolecular interactions can lead to false predictions.

You do not need to provide an email adress, a link to the results will be returned. If you provide an email address, results will also be sent to this address. Please make sure that the email address is correct. Your e-mail will not be shared with any third parties. Input files, results, and e-mails will be stored up to 7 days after which they are permanently deleted. After this point, if you need support you will have to re-submit your calculations.

SAMPLE RUN: Please, click here.

QUESTIONS? Please, have a look here.

For questions, please do not hesitate to contact support[at]

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